00714nas a2200145   4500000000100000000000100001008004100002260000900043100001400052700001600066700001900082245007300101300001400174520038000188       2013                            d  bIEEE1 aB. Strack1 aK.M. Jacobs1 aKrzysztof Cios00aSimulating lesions in multi-layer, multi-columnar model of neocortex  a835–8383 aThe paper presents results of modeling global and focal loss of layers in a multi-columnar model of neocortex. Specifically, the spread of activity across columns in conditions of inhibitory blockade is compared. With very low inhibition activity spreads through all layers, however, deep layers are critical for spread of activity when inhibition is only moderately blocked.