01198nas a2200133   4500000000100000000000100001008004100002260004000043100002100083700001800104245008500122300001400207520084300221       2005                            d  bSpringer-VerlagaBerlin Heildelberg1 aLech Znamirowski1 aV.S. Sunderam00aNon-gradient, Sequential Algorithm for Simulation of Nascent Polypeptide Folding  a766–7743 aIn the paper, the method for determining of the conformation of nascent protein folding based on two-phase, sequential simulation approach is presented. In both phases the potential energy of molecule under construction is minimized, however in the first phase the minimization is performed for the structure {new amino acid}/{existing amino acid chain} and in the second phase, the {new existing amino acid chain} conformation is “tuned” to reach the minimal potential energy of growing chain. The formed, nascent conformation of protein determines initial condition for a future conformation modifications and plays a crucial role in fixing the biological and chemical features of created protein. The simulation of conformation process is illustrated through the numerical example of nascent protein folding for a selected protein.