TY - CPAPER AU - B. Strack AU - K.M. Jacobs AU - Krzysztof Cios AB - The paper presents results of modeling global and focal loss of layers in a multi-columnar model of neocortex. Specifically, the spread of activity across columns in conditions of inhibitory blockade is compared. With very low inhibition activity spreads through all layers, however, deep layers are critical for spread of activity when inhibition is only moderately blocked. BT - Proceedings LA - eng N1 - 6th annual International IEEE EMBS Conference on Neural Engineering San Diego, California, 6-8 November, 2013 N2 - The paper presents results of modeling global and focal loss of layers in a multi-columnar model of neocortex. Specifically, the spread of activity across columns in conditions of inhibitory blockade is compared. With very low inhibition activity spreads through all layers, however, deep layers are critical for spread of activity when inhibition is only moderately blocked. PB - IEEE PY - 2013 EP - 835–838 T2 - Proceedings TI - Simulating lesions in multi-layer, multi-columnar model of neocortex ER -